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Summary:

"Biochemical abnormalities play a key role in human illness. To pinpoint effective curative solutions, biochemical pharmacologists use drugs to discover new information about biosynthetic pathways and their kinetics. Using a more chemistry- and mechanism-oriented approach than standard pharmacology books, Introduction to Biochemical Pharmacology is a one-stop reference that focuses on how a drug interacts with a target receptor or enzyme at the molecular level. Learning is reinforced through the use of end-of-chapter exercises, PowerPoint slides, and a problem-and-solutions manual"--Provided by publisher.

Table of Contents:

• Machine generated contents note: 1. Introduction
• 1.1. Origin and preparation of drugs
• 1.2. Drugs and drug targets
• 1.3. Drug molecules may or may not resemble the physiological ligands of their receptors
• 1.4. Strategies of drug discovery and development
• References
• 2. Pharmacodynamics
• 2.1. Molecular features of drug-receptor interaction
• 2.2. Theory of drug-receptor binding
• 2.3. Dose-effect relationships in signaling cascades
• 2.4. Potency and efficacy
• 2.5. Beneficial and toxic drug effects
• 2.6. Appendix
• Study questions
• References
• 3. Pharmacokinetics
• 3.1. Anatomical barriers to drug transport
• 3.2. Solute transport across cell membranes
• 3.3. Drug application
• 3.4. Drug distribution

• 3.5. Drug elimination via the kidneys
• 3.6. Quantitative experimental methods in pharmacokinetics
• Study questions
• References
• 4. Drug metabolism
• 4.1. Overview: Possible functional outcomes of drug metabolism
• 4.2. Phase I and phase II reactions
• 4.3. Cytochrome P450
• 4.4. Reductive drug metabolism
• 4.5. Conjugation reactions
• 4.6. Enzyme induction
• 4.7. Metabolism-related toxicity as a therapeutic target
• Study questions
• References
• 5. G protein-coupled receptors
• 5.1. Overview
• 5.2. GPCR structure
• 5.3. Structural GPCR families
• 5.4. Activation of GPCRs
• 5.5. GPCR dimerization and oligomerization
• 5.6. G proteins
• 5.7. GPCR phosphorylation, endocytosis, and G protein-independent signaling
• 5.8. Appendix
• Study questions
• References
• 6. Pharmacology of cell excitation
• 6.1. Ions, pumps, and channels
• 6.2. ATP-driven active ion transport
• 6.3. Voltage-gated channels and the action potential
• 6.4. Channels controlled by intracellular ligands
• 6.5. Transient receptor potential (TRP) channels
• 6.6. Voltage-gated channels of nerve cells as drug targets
• 6.7. Synaptic transmission
• 6.8. Pharmacology of individual transmitters
• 6.9. Appendix
• Study questions
• References
• 7. Hormones
• 7.1. Hormone receptors
• 7.2. hypothalamus and the pituitary gland
• 7.3. Thyroid gland hormones
• 7.4. Steroid hormones
• 7.5. Endocrine control of bone mineralization
• Study questions
• References
• 8. Pharmacology of nitric oxide
• 8.1. Characterization of nitric oxide as a biological signaling molecule
• 8.2. Nitric oxide synthase and its isoforms
• 8.3. Biochemical mechanisms of NO signaling
• 8.4. biological function of iNOS
• 8.5. NO-releasing drugs
• 8.6. NOS inhibitors
• 8.7. Phosphodiesterase inhibitors
• Study questions
• References
• 9. Eicosanoid mediators and related drugs
• 9.1. Biosynthesis of eicosanoids
• 9.2. cyclooxygenase reaction
• 9.3. Cyclooxygenase isoforms and inhibitors
• 9.4. Phospholipase A2 inhibitors
• 9.5. Derivatives of prostaglandin H2 and related drugs
• 9.6. Lipoxygenases, leukotrienes, and related drugs
• 9.7. Eicosanoids synthesized by cytochrome P450
• 9.8. Endocannabinoids and related drugs
• 9.9. role of polyunsaturated fatty acids in eicosanoid signaling
• Study questions
• References
• 10. Intermediate metabolism, diabetes and atherosclerosis
• 10.1. Hereditary enzyme defects
• 10.2. Gout
• 10.3. Diabetes mellitus
• 10.4. Atherosclerosis
• Study questions
• References
• 11. Chemotherapy of infectious diseases
• 11.1. Pathogenic microbes: Diversity and selective toxicity
• 11.2. Pharmacokinetic considerations
• 11.3. Resistance to antimicrobials
• 11.4. Antibacterial chemotherapy
• 11.5. Chemotherapy of fungal infections
• 11.6. Chemotherapy of parasite infections
• 11.7. Antiviral chemotherapy
• Study questions
• References
• 12. Tumor chemotherapy
• 12.1. Some principles of tumor biology
• 12.2. Cell-type-specific antitumor drugs
• 12.3. Drugs that target specific oncoproteins
• 12.4. Cytotoxic antitumor drugs
• Study questions
• References
• 13. Ribonucleic acids as drug targets and drugs
• 13.1. RNA as drug target
• 13.2. RNA as a therapeutic agent
• Study questions
• References
• 14. Drug delivery
• 14.1. Improving intestinal drug absorption
• 14.2. Improving drug distribution
• 14.3. Targeted drug delivery
• 14.4. Kinetically controlled drug release
• 14.5. Controlling drug toxicity
• 14.6. Delivery of nucleic acids
• Study questions
• References
• 15. Drug discovery
• 15.1. Target selection and validation
• 15.2. Screening of candidate compounds
• 15.3. Computational screening
• 15.4. Phenotypic screening
• 15.5. Compound acquisition
• Study questions
• References
• Answers to study questions
• References.

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Author/Creator:

Palmer, Michael, 1961 May 4-

Languages:

English

Language Notes:

Item content: English

Main Work:

Biochemical pharmacology [by Palmer, M.]

Other Related Resources:

Print version: Biochemical pharmacology [by Palmer, M.] (1st ed.; Hoboken, New Jersey : John Wiley & Sons, ©2012 — ISBN 9780470174456; LCCN 2011041617)

Subjects:

Drug interactions

Pharmacokinetics

General Notes:

Includes bibliographical references and index.
Electronic reproduction. Palo Alto, Calif. Available via World Wide Web.
Description based on: Print version record.

Physical Description:

1 online resource.

Digital Characteristics:

text file

Call Numbers:

RM302 .P35 2012eb

ISBNs:

9781118230367 (electronic bk.)
1118230361 (electronic bk.)
9780470174456 (electronic bk.)
0470174455 (electronic bk.)

OCLC Numbers:

785407739

Other Control Numbers:

EBC821892 (source: MiAaPQ)